کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5221553 1383423 2011 19 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Formal synthesis of (+)-neooxazolomycin via a Stille cross-coupling/deconjugation route
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Formal synthesis of (+)-neooxazolomycin via a Stille cross-coupling/deconjugation route
چکیده انگلیسی

A formal synthesis of neooxazolomycin is described via the preparation of Kende's key intermediate in a longest linear sequence of 23 steps. This work is founded upon the union of three fragments: Moloney's lactam-derived triflate, a vinyl stannane and a Julia-Kocienski sulfone and encompasses three key steps: (i) a Stille cross-coupling to combine the triflate and vinyl stannane, (ii) a base-promoted enone deconjugation to derive the dihydroxylation precursor and (iii) our previously reported Julia-Kocienski methodology to assemble the pentadienyl amine side chain with the sulfone precursor.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Tetrahedron - Volume 67, Issue 51, 23 December 2011, Pages 10026-10044
نویسندگان
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