کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5221770 | 1383431 | 2010 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Synthesis of neamine-carboline conjugates for RNA binding and their antibacterial activities
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Synthesis of neamine-carboline conjugates for RNA binding and their antibacterial activities Synthesis of neamine-carboline conjugates for RNA binding and their antibacterial activities](/preview/png/5221770.png)
چکیده انگلیسی
Three types of neamine-β-carboline conjugates were synthesized in good yields by the coupling of neamine and β-carboline-3-carboxylic acids using aliphatic diamine as a linker. The binding properties of these conjugates to 16S rRNA and 18S rRNA were evaluated by surface plasmon resonance (SPR), showing that some conjugates had stronger binding affinities than neamine. In vitro antimicrobial activities were also evaluated and the results showed that some synthetic compounds exhibited better antibacterial activities than neamine. The preliminary structure-activity relationship was discussed. The present experimental data demonstrated that synthetic neamine-carboline conjugates might hold the potential as new antibiotics.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Tetrahedron - Volume 66, Issue 19, 8 May 2010, Pages 3433-3440
Journal: Tetrahedron - Volume 66, Issue 19, 8 May 2010, Pages 3433-3440
نویسندگان
Shan Wu, Yunsha Fu, Ribai Yan, Yanfen Wu, Xiaoping Lei, Xin-Shan Ye,