کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5221830 1383433 2011 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Pulcherrins D-R, potential anti-inflammatory diterpenoids from the roots of Caesalpinia pulcherrima
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Pulcherrins D-R, potential anti-inflammatory diterpenoids from the roots of Caesalpinia pulcherrima
چکیده انگلیسی

Bioactivity-guided isolation and purification of the dichloromethane extract from the roots of Caesalpinia pulcherrima yielded 15 new cassane-type diterpenes, named pulcherrins D-R (1-15) together with eight known compounds. The structures of the new metabolites were determined on the basis of spectroscopic analyses including 1D- and 2D-NMR and mass spectroscopy. The anti-inflammatory activity of isolated compounds was investigated with the lipopolysaccharide (LPS)-induced murine macrophage RAW 264.7 cell lines. Compounds 8, 9, 11-15, and 17-23 showed potent NO inhibitory activity.

Fifteen new cassane-type diterpenes, named pulcherrins D-R, as well as eight known NO inhibitors, were isolated from the roots of Caesalpinia pulcherrima.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Tetrahedron - Volume 67, Issue 36, 9 September 2011, Pages 6838-6846
نویسندگان
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