کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5221860 | 1383434 | 2010 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Synthesis of substituted β-carbolines via gold(III)-catalyzed cycloisomerization of N-propargylamides
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موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Indole-substituted N-propargylamides undergo a gold(III)-catalyzed cyclization to give oxazoles or β-carbolinones, depending on the substitution pattern at the amide nitrogen. Secondary amides furnished oxazoles via a 5-exo-dig cyclization, while tertiary indole-2-carboxamides cycloisomerized to give 2,9-dihydro-β-carbolin-1-ones upon treatment with catalytic amounts of gold(III) chloride. An optimized procedure was developed to prepare several new N-benzyl-β-carbolinones as well as the corresponding β-carbolines, which are of interest as core structures found in various natural products such as the harman, ervolanine, and lavendamycin class of alkaloids.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Tetrahedron - Volume 66, Issue 7, 13 February 2010, Pages 1496-1502
Journal: Tetrahedron - Volume 66, Issue 7, 13 February 2010, Pages 1496-1502
نویسندگان
Guido Verniest, Dylan England, Norbert De Kimpe, Albert Padwa,