کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5221968 | 1383438 | 2011 | 5 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Cyclopeptides and polyketides from coral-associated fungus, Aspergillus versicolor LCJ-5-4 Cyclopeptides and polyketides from coral-associated fungus, Aspergillus versicolor LCJ-5-4](/preview/png/5221968.png)
Three new cyclopentapeptides, versicoloritides A-C (1-3), a new orcinol tetramer, tetraorcinol A (4), and two new lactones, versicolactones A and B (5 and 6) together with three known metabolites, diorcinol, glyantrypine, and cordyol C were isolated from the fermentation broth of the coral-associated fungus Aspergillus versicolor LCJ-5-4. Their structures were elucidated by spectroscopic and chemical methods. The new compounds 1-4 were evaluated for their radical-scavenging activity and antimicrobial activity against Staphylococcus aureus, Escherichia coli, Enterobacter aerogenes, Bacillus subtilis, Pseudomonas aeruginosa, and Candida albicans and cytotoxicity against P388 and Hela cell lines. Compound 4 showed weak radical-scavenging activity against the DPPH radical with an IC50 value of 67 μM.
Journal: Tetrahedron - Volume 67, Issue 37, 16 September 2011, Pages 7085-7089