New dibenzocyclooctadiene lignans from the Kadsura ananosma

Fourteen new dibenzocyclooctadiene lignans, ananonins A–N (1–14), together with five known compounds, were isolated from the seeds of Kadsura ananosma. The structures and absolute configurations of 1–14 were established using a combination of MS, NMR, and CD techniques. The biological activity of these compounds was evaluated, and ananonin M (13) showed moderate neuroprotective effects in an in vitro assay.

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