کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5222427 1383454 2009 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Synthesis of undecaprenyl pyrophosphate-linked glycans as donor substrates for bacterial protein N-glycosylation
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Synthesis of undecaprenyl pyrophosphate-linked glycans as donor substrates for bacterial protein N-glycosylation
چکیده انگلیسی

Synthesis of undecaprenyl pyrophosphate (Und-PP)-linked glycans is described. Bacterial ([E]3,[Z]7)-undecaprenol was synthesized from trans-geranylgeranyl sulfone and isoprenoid building blocks, which was converted to undecaprenyl phosphate (Und-P). It was coupled with glycosyl phosphates to afford Und-PP-linked glycans, including core trisaccharide of Campylobacter jejuni N-glycan. Our synthetic method for Und-PP-linked glycan would provide various substrates as a useful tool for systematic analysis of bacterial protein N-glycosylation.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Tetrahedron - Volume 65, Issue 32, 8 August 2009, Pages 6310-6319
نویسندگان
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