One-pot three components synthesis of O-acetylcyanohydrins with TMSCN, acetic anhydride and carbonyl compounds under solvent-free condition

One-pot three components synthesis of O-acetylcyanohydrins has been developed in the presence of B(C6F5)3 as the catalyst. Variety of aldehydes or ketones reacts with TMSCN and acetic anhydride (Ac2O) under the influence of 1 mol % of B(C6F5)3 to give good to excellent yield of the products without solvent at rt.

Variety of aldehydes or ketones react with TMSCN and acetic anhydride (Ac2O) to give good to excellent yield of the O-acetylcyanohydrins under the influence of 1 mol % of B(C6F5)3 without solvent at rt. The major advantage of the method is the lowest catalyst quantity under solvent-free condition.