Preparation of the major urinary metabolite of (−)-prostaglandin E2

The best way to measure whole body production of the locally acting hormone prostaglandin E2 (PGE2) is to assess the accumulation of the major urinary metabolite, PGE2UM. A practical preparation of this delicate diacid is described. This synthetic PGE2UM will enable production of the antibodies that will be used to quantify this key metabolite.

The best way to measure whole body production of the locally acting hormone prostaglandin E2 (PGE2) is to assess the accumulation of the major urinary metabolite, PGE2UM. A practical preparation of this delicate diacid is described. This synthetic PGE2UM will enable production of the antibodies that will be used to quantify this key metabolite.