کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5222730 1383464 2009 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Influence of α-methyl substitution of proline-based organocatalysts on the asymmetric α-oxidation of aldehydes
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Influence of α-methyl substitution of proline-based organocatalysts on the asymmetric α-oxidation of aldehydes
چکیده انگلیسی

The direct asymmetric organocatalytic α-oxidation of aldehydes using trans-2-(p-methylphenylsulfonyl)-3-phenyloxaziridine is reported. This method affords the S isomer of α-hydroxy aldehydes, thereby complementing the selectivity for the R isomer observed using the two-step nitrosobenzene method. Use of α-methylproline and α-methylproline tetrazole significantly increases the enantioselectivity observed for the α-oxidation of aldehydes compared to analogous unsubstituted organocatalysts.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Tetrahedron - Volume 65, Issue 25, 20 June 2009, Pages 4801-4807
نویسندگان
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