کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5222737 | 1383464 | 2009 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Synthesis of diversely functionalized pyrrolizidines and indolizidines using olefin ring-closing metathesis
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موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Various nitrogen-fused tricyclic compounds, having benzoindolizidine and benzopyrrolizidines ring systems were synthesized via ene–ene metathesis using the first and second-generation Grubbs catalyst. The ene–ene metathesis proceeded smoothly in refluxing CH2Cl2 with 3.0 mol % of G1, giving good yields (78–86%) of the benzoindolizidine products 12a,b. The benzopyrrolizidine 6 was prepared after optimization in 64% yield by using 5.0+5.0 mol % of G2. The resulting olefin moiety of the indolizidine framework is a suitable precursor for polyhydroxy structures via the Sharpless process. The structures of the polyhydroxylated adducts were determined by 1H NMR spectra and single-crystal X-ray analysis.
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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Tetrahedron - Volume 65, Issue 25, 20 June 2009, Pages 4846–4854
Journal: Tetrahedron - Volume 65, Issue 25, 20 June 2009, Pages 4846–4854