کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5222862 1383468 2011 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Facile calculation of specific rate constants and activation energies of 18F-fluorination reaction using combined processes of coat-capture–elution and microfluidics
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Facile calculation of specific rate constants and activation energies of 18F-fluorination reaction using combined processes of coat-capture–elution and microfluidics
چکیده انگلیسی

Calculation of a specific rate constant (k) and activation energy (Ea) of 18F-labeling reaction is important to obtain objective data. However, it has never been tried, because short time heating required for the calculation of the parameters was difficult. In the present study, we could calculate the parameters using combination of coat-capture–elution method (Aerts et al.) and microfluidic processes. The Ea values obtained for Ts-naphthol in acetone, MeCN and t-BuOH were 5.83, 8.98, and 13.54 kcal/mol, respectively, and for Ms-naphthol in the same solvents were 5.81, 8.16, and 19.34 kcal/mol, respectively. Calculation of these parameters might be useful for setting up [18F]fluorination procedure and for developing new precursors.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Tetrahedron - Volume 67, Issue 13, 1 April 2011, Pages 2427–2433