کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5222863 1383468 2011 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Convergent stereoselective and efficient synthesis of furanic-steroid derivatives
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Convergent stereoselective and efficient synthesis of furanic-steroid derivatives
چکیده انگلیسی

The stereoselective synthesis of furanic-steroid derivatives involving ring-closing metathesis and catalytic hydrogenation as key steps is described. The synthetic strategy was first illustrated by the synthesis of the furanic-estrane derivative 1 in seven steps starting from estrone and 2-methylene-propane-1,3-diol. This compound initially targeted as a potential inhibitor of 17β-hydroxysteroid dehydrogenase type 1 by a docking experiment was found to inhibit the enzyme. The scope of this new strategy was also extended to furanic-androstane derivatives by synthesizing compound 20.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Tetrahedron - Volume 67, Issue 13, 1 April 2011, Pages 2434-2440
نویسندگان
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