Applanatines A–E from the culture broth of Ganoderma applanatum

Five novel compounds, applanatines A–E (1–5), and a known one (6) were isolated from the culture broth of Ganoderma applanatum. Their structures including the relative configurations were determined by the interpretation of spectroscopic data. Compounds 3 and 4 suppressed the growth of Fusobacterium nucleatum, that is, a prominent member of the oral microflora implicated in periodontitis.

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