کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5222966 1383472 2010 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Synthesis of quinoline thioethers as novel small molecule enhancers of monoclonal antibody production in mammalian cell culture
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Synthesis of quinoline thioethers as novel small molecule enhancers of monoclonal antibody production in mammalian cell culture
چکیده انگلیسی

A small library of novel quinoline derivatives containing different thioether substituents at position 4 have been synthesized and screened in murine hybridoma cell culture for their ability to enhance monoclonal antibody (mAb) production. From this set of compounds, four compounds have been discovered that enhanced immunoglobulin G (IgG) titer over negative control cultures due to an increase in specific productivity. These results demonstrate the utility of using organic synthesis and parallel ligand screening methods to discover novel cell culture additives that may be useful for increasing mAb yield in industrial biomanufacturing processes.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Tetrahedron - Volume 66, Issue 48, 27 November 2010, Pages 9461-9467
نویسندگان
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