کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5223186 | 1383479 | 2009 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Regioselective synthesis of folic acid conjugates from diether-type archaeal lipid analogues
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موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Regioselective synthesis of folic acid conjugates from diether-type archaeal lipid analogues Regioselective synthesis of folic acid conjugates from diether-type archaeal lipid analogues](/preview/png/5223186.png)
چکیده انگلیسی
A regioselective access to both α- and γ-folic acid conjugates derived from archaeal lipid analogues is described. The synthetic approach is based on conveniently protected glutamates that led first to α- and γ-glutamate derivatives. The final reconstruction of the folic acid moiety was achieved through the reaction of a protected/activated pteroate followed by a simple deprotection step. These α- and γ-folic acid conjugates would permit to establish the importance of a regiocontrolled introduction of folic acid on the folic acid/folate receptor interaction in the case of a targeted drug/gene delivery.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Tetrahedron - Volume 65, Issue 7, 14 February 2009, Pages 1455-1460
Journal: Tetrahedron - Volume 65, Issue 7, 14 February 2009, Pages 1455-1460
نویسندگان
Céline Lainé, Clémence Mocquet, Loïc Lemiègre, Thierry Benvegnu,