کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5223490 1383488 2008 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Novel multicomponent reactions of primary amines and alkyl propiolates with alloxan derivatives in water
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Novel multicomponent reactions of primary amines and alkyl propiolates with alloxan derivatives in water
چکیده انگلیسی

A water-accelerated multicomponent synthesis of organic target molecules has been used as a key method for the preparation of novel barbiturate derivatives. The three-component condensation reactions of primary amines with alkyl propiolates in the presence of alloxan derivatives in water are developed as efficient and clean green synthetic procedures for the high-yielding preparation of alkyl 2-(5-hydroxy-2,4,6-trioxohexahydro-5-pyrimidinyl)-3-(alkyl or arylamino)-2-propenoates. The above synthetic protocol provides rapid access to novel and diversely substituted barbiturate derivatives.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Tetrahedron - Volume 64, Issue 45, 3 November 2008, Pages 10425-10430
نویسندگان
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