Cs2.5H0.5PW12O40 catalyzed diastereoselective synthesis of β-amino ketones via three component Mannich-type reaction in water

A series of insoluble salts of Keggin heteropoly compounds were prepared and used as catalysts for the Mannich-type reaction of benzaldehyde, aniline, and cyclohexanone in water. Among them, Cs2.5H0.5PW12O40 showed excellent catalytic activity. Effects of surfactant, catalyst loading and temperature were studied to introduce the best reaction condition. The optimized reaction conditions were extended to Mannich reaction of various aldehydes, ketones, and amines in water. This rapid procedure afforded structurally divers β-amino ketones with major anti diastereoselectivity. Additionally, four new compounds were reported. The catalyst was recovered and reused for subsequent runs.

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