Synthesis of pyrimido[6,1-a]isoquinolines via a one-pot, four-component reaction

An efficient one-pot synthesis of pyrimido[6,1-a]isoquinoline-1-carboxylate derivatives is described. This involves the four-component reaction between primary amines, alkyl acetoacetates, isoquinoline and trichloromethylchloroformate (diphosgene) under mild conditions at ambient temperature.

A facile and direct synthetic entry to pyrimido[6,1-a]isoquinolines via a one-pot, four-component reaction of primary amines and alkyl acetoacetates, isoquinoline and trichloromethylchloroformate (diphosgene) under mild conditions at ambient temperature is reported.Figure optionsDownload as PowerPoint slide