کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5223819 | 1383499 | 2010 | 10 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Biomimetic rearrangements of simplified labdane diterpenoids
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موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Biomimetic rearrangements of simplified labdane diterpenoids Biomimetic rearrangements of simplified labdane diterpenoids](/preview/png/5223819.png)
چکیده انگلیسی
Simplified ethyl-substituted labdane diterpenoids 14 and 19 have been synthesised from (+)-sclareolide (18). Biomimetic rearrangements of these compounds, involving stereospecific 1,2-alkyl and hydride shifts, have been carried out by treatment with a variety of Lewis and protic acids. Halimane compounds, such as 34 and simple dehydration products such as 3, 32 and 33 have been formed either selectively or as mixtures depending on the reaction conditions. However, further rearrangement to clerodane products such as 1 and 2 was not observed, indicating a high degree of enzymatic control for the in vivo formation of these natural products.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Tetrahedron - Volume 66, Issue 33, 14 August 2010, Pages 6321-6330
Journal: Tetrahedron - Volume 66, Issue 33, 14 August 2010, Pages 6321-6330
نویسندگان
Jonathan H. George, Mark McArdle, Jack E. Baldwin, Robert M. Adlington,