Globular carbosilane dendrimers with mannose groups at the periphery: synthesis, characterization and toxicity in dendritic cells

A synthetic strategy has been developed for the preparation of new globular carbosilane dendrimers with mannose groups at the periphery. It consists of hydrosilylation reaction of allyl tetraacetylmannose with carbosilane dendrimers containing monohydrosilane end groups and the subsequent deacetylation reaction. Evaluation of dendrimer toxicities in dendritic cells by MTT assay were carried out, and evidence a good biocompatibility.