Trigochinins D–I: six new daphnane-type diterpenoids from Trigonostemon chinensis

Six new highly oxygenated daphnane-type diterpenoids, trigochinins D–I (1–6), were isolated from the twigs and leaves of Trigonostemon chinensis. Their structures with the absolute configuration were established on the basis of spectroscopic method and CD analysis. Trigochinins D–F (1–3) possessed a rare 4,6-oxetane moiety in this compound class. Trigochinins E and F exhibited significant inhibiting activity against HL-60 tumor cell line.

Six new highly oxygenated daphnane-type diterpenoids, trigochinins D–I (1–6), were isolated from Trigonostemon chinensis. Their structures with the absolute configuration were determined by spectroscopic method and CD analysis. Trigochinins E and F exhibited inhibition on HL-60 tumor cell line.Figure optionsDownload as PowerPoint slide