Pd(II)-catalyzed coupling-cyclization reaction of o-ethylnylphenylphosphonamides monoesters with allyl halide

4-Allyl-phosphaisoquinolin-1-ones were synthesized by palladium-catalyzed coupling-cyclization of o-ethynylphenylphosphonamide monoethyl esters with allyl halides with high regioselectivity and good yields. The synthesized 4-allyl-phosphaisoquinolin-1-ones show bioactivity as inhibitor of MCH-1R.