کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5224131 1383507 2010 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Structure and absolute configuration of 3-alkylpiperidine alkaloids from an Indonesian sponge of the genus Halichondria
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Structure and absolute configuration of 3-alkylpiperidine alkaloids from an Indonesian sponge of the genus Halichondria
چکیده انگلیسی

Chemical analysis of an Indonesian sponge sample has provided three new 3-alkylpiperidine alkaloids, tetradehydrohaliclonacyclamine A, its mono-N-oxide derivative, and a 2-epi isomer. The absolute structure of tetradehydrohaliclonacyclamine A has been established by X-ray crystallography from anomalous dispersion effects using Cu radiation, which determined that the absolute configuration is 2S, 3S, 7S, 9S while an HPLC study revealed that the alkaloid is enantiomerically pure.

The structure and relative configuration of three new 3-alkylpiperidines, tetradehydrohaliclonacyclamine A 10, its mono-N-oxide 11, and the C-2 epimer 12, have been deduced by 2D NMR spectroscopy. An X-ray crystallographic study has provided the absolute configuration of 10.Figure optionsDownload as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Tetrahedron - Volume 66, Issue 14, 3 April 2010, Pages 2752–2760