کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5224235 | 1383511 | 2008 | 15 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Structural diversification of taxanes by whole-cell biotransformation
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موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Structural diversification of taxanes by whole-cell biotransformation Structural diversification of taxanes by whole-cell biotransformation](/preview/png/5224235.png)
چکیده انگلیسی
The structural diversification of four 4(20),11(12)-taxadienes (sinenxan A and its two derivatives, and yunanxane) by microbial/plant whole-cell enzymatic transformation has been achieved; 53 derivatives have been obtained, and 41 of them are new compounds. The occurred reactions exhibited diversity, including hydroxylation, epoxidation, oxidation, hydrolysis, acylation, O-alkylation, O-glycosylation, rearrangement, etc. In addition, one chemical derivative, 9α-cinnamoyl sinenxan A from one enzymatic product 9α-hydroxyl sinenxan A, displayed significant reversal activity toward three MDR tumor cell lines (A549/taxol, KB/VCR, and HCT-8).
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Tetrahedron - Volume 64, Issue 35, 25 August 2008, Pages 8102-8116
Journal: Tetrahedron - Volume 64, Issue 35, 25 August 2008, Pages 8102-8116
نویسندگان
Jungui Dai, Runjiang Qu, Jian-hua Zou, Xiaoguang Chen,