کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5224266 1383512 2009 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Empirical method for predicting enantioselectivity in catalytic reactions: demonstration with lipase and oxazaborolidine
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Empirical method for predicting enantioselectivity in catalytic reactions: demonstration with lipase and oxazaborolidine
چکیده انگلیسی

We derived a novel equation capable of predicting the degree of enantioselectivity in a catalytic reaction without any knowledge of the reaction mechanism and/or the transition-state structure, and tested the validity of this equation by changing substrates systematically in the lipase or oxazaborolidine-catalyzed reactions. A good correlation was observed between the predicted and observed E values, and the stereochemistry of the products could be predicted correctly in most cases (28 out of 30).

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Tetrahedron - Volume 65, Issue 46, 14 November 2009, Pages 9583-9591
نویسندگان
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