کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5224326 | 1383514 | 2010 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Al-MCM-41 catalyzed three-component Strecker-type synthesis of α-aminonitriles
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Mesoporous aluminosilicate (Al-MCM-41) efficiently catalyzed the three-component Strecker-type reaction of benzylacetone and aniline with trimethylsilyl cyanide in CH2Cl2 at room temperature to afford the corresponding α-aminonitrile in excellent yields (up to 97%). Mesoporous silica (MCM-41), amorphous SiO2-Al2O3, and H-Y and H-ZSM-5 zeolites also catalyzed this reaction, but gave the desired product in lower yields. The Al-MCM-41 catalyzed three-component Strecker-type reaction was applicable to a wide range of ketones, aldehydes, and amines. Furthermore, the Al-MCM-41 catalyst could be applied to a fixed-bed flow reactor: The desired α-aminonitrile derivative was constantly produced in nearly 80% yields for 48 h.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Tetrahedron - Volume 66, Issue 10, 6 March 2010, Pages 1898-1901
Journal: Tetrahedron - Volume 66, Issue 10, 6 March 2010, Pages 1898-1901
نویسندگان
Katsuyuki Iwanami, Hana Seo, Jun-Chul Choi, Toshiyasu Sakakura, Hiroyuki Yasuda,