کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5224433 | 1383517 | 2009 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Synthesis of an hexadentate tricyclic tetraazadiacetic ligand as precursor for MRI contrast enhancement agents
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موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Synthesis of an hexadentate tricyclic tetraazadiacetic ligand as precursor for MRI contrast enhancement agents Synthesis of an hexadentate tricyclic tetraazadiacetic ligand as precursor for MRI contrast enhancement agents](/preview/png/5224433.png)
چکیده انگلیسی
A tricyclic tetraazadiacetic compound, which is a rigidified derivative of cyclo-PCTA12 ligand with an oxo-ethylene bridge replacing an ethylene one, was prepared. The synthetic route involved the macrocyclization between an activated amido-disulfonamide and the 2,6-bis(bromomethyl)pyridine. The acetate side chains were grafted on the macrocyclic backbone to lead to the highly rigid tricyclic ligand in 34% overall yield in four steps from the linear amido-disulfonamide precursor. The corresponding Gd(III) and Mn(II) complexes were then prepared in order to evaluate their potential as contrast agent for MRI.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Tetrahedron - Volume 65, Issue 36, 5 September 2009, Pages 7573-7579
Journal: Tetrahedron - Volume 65, Issue 36, 5 September 2009, Pages 7573-7579
نویسندگان
Fabienne Dioury, Clotilde Ferroud, Alain Guy, Marc Port,