کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5224442 | 1383517 | 2009 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Synthesis of (±)-4â²-ethynyl-5â²,5â²-difluoro-2â²,3â²-dehydro-3â²-deoxy- carbocyclic thymidine: a difluoromethylidene analogue of promising anti-HIV agent Ed4T
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موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله

چکیده انگلیسی
Synthesis of (±)-4â²-ethynyl-5â²,5â²-difluoro-2â²,3â²-dehydro-3â²-deoxy-carbocyclic-thymidine (8) was carried out. The difluoromethylylidene group of 8 was constructed by the electrophilic fluorination to the cyclopentenone 11 by using Selectfluor®. Introduction of thymine base was investigated based on the Mitsunobu reaction by employing cyclopentenyl allyl alcohols variously substituted at the 4-position. It was found the 4-methoxycarbonyl derivative 14 gave the highest selectivity both in terms of regio- and stereochemistry.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Tetrahedron - Volume 65, Issue 36, 5 September 2009, Pages 7630-7636
Journal: Tetrahedron - Volume 65, Issue 36, 5 September 2009, Pages 7630-7636
نویسندگان
Hiroki Kumamoto, Kazuhiro Haraguchi, Mayumi Ida, Kazuo T. Nakamura, Yasuyuki Kitagawa, Takayuki Hamasaki, Masanori Baba, Satoko Shimbara Matsubayashi, Hiromichi Tanaka,