کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5224649 1383524 2008 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Synthesis of 1,4-thiazino- and benzo-1,4-thiazinomorphinans: their acid-catalyzed rearrangement and study of the formation of unexpected oxidation products
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Synthesis of 1,4-thiazino- and benzo-1,4-thiazinomorphinans: their acid-catalyzed rearrangement and study of the formation of unexpected oxidation products
چکیده انگلیسی

The formation of 1,4-thiazine and benzo-1,4-thiazine rings was performed at the 6,7-positions of the morphinan backbone in order to synthesize systems annulated with a new six-membered ring providing potential pharmacological activity and the opportunity of easy functionalization. An unexpected oxidation of cyclic sulfur was observed in both cases affording either sulfones or open-ringed bis-morphinan-type by-product. These phenomena are in conformity with the observations and mechanistic explanations made by several research groups in the past in connection with the photosensitized oxidation of cyclic sulfides.

The formation of 1,4-thiazine and benzo-1,4-thiazine rings was performed at the 6,7-positions of the morphinan backbone in order to synthesize systems annulated with a new six-membered ring providing potential pharmacological activity and the opportunity of easy functionalization. An unexpected oxidation of cyclic sulfur was observed in both cases affording either sulfones or open-ringed bis-morphinan-type by-product.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Tetrahedron - Volume 64, Issue 6, 4 February 2008, Pages 1023-1028
نویسندگان
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