A convenient synthesis and cytotoxic evaluation of N-unsubstituted α-methylene-γ-lactams

Chemoselective reduction of 3-aryl-2-diethoxyphosphoryl-4-nitroalkanoates provided the corresponding α-diethoxyphosphoryl-γ-lactams in completely diastereoselective manner. The products were shown to be useful substrates for the synthesis of mono-β-substituted and β,γ-disubstituted α-methylene-γ-lactams. Cytotoxicity of these compounds was evaluated.

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