کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5224915 | 1383532 | 2010 | 11 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Structure elucidation and stereoselective total synthesis of pavettamine, the causal agent of gousiekte
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موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Structure elucidation and stereoselective total synthesis of pavettamine, the causal agent of gousiekte Structure elucidation and stereoselective total synthesis of pavettamine, the causal agent of gousiekte](/preview/png/5224915.png)
چکیده انگلیسی
The structure elucidation of a novel natural product pavettamine (1), the causal agent of the plant toxicosis gousiekte, is reported. The structure was defined by analysis of NMR and MS data and the relative configuration followed from the 13C NMR data of the acetonide derivative. The absolute stereochemistry was established by total synthesis from (2S)-malic acid using chiral sulfoxide methodology as (2S,4R,8R,10S)-1,11-diamino-6-aza-undecane-2,4,8,10-tetraol.
The structure and relative configuration of a novel natural product, pavettamine, was defined by analysis of NMR and MS data. The absolute stereochemistry was established by total synthesis from (2S)-malic acid using chiral sulfoxide methodology.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Tetrahedron - Volume 66, Issue 11, 13 March 2010, Pages 2026-2036
Journal: Tetrahedron - Volume 66, Issue 11, 13 March 2010, Pages 2026-2036
نویسندگان
Moira L. Bode, Paul J. Gates, Samson Y. Gebretnsae, Robert Vleggaar,