The synthesis of single enantiomers of mycobacterial ketomycolic acids containing cis-cyclopropanes

We report the syntheses of a single enantiomer of an unprotected ketomycolic acids containing a cis-cyclopropane and of related hydroxy-mycolic acids.

The syntheses of single enantiomers of protected ketomycolic acids containing a cis-cyclopropane, and of related hydroxy-mycolic acids and a chemical method for deprotection of the ketomycolate derivatives without epimerisation are reported.