کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5225478 1383548 2008 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The conformational features of palytoxin in aqueous solution
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
The conformational features of palytoxin in aqueous solution
چکیده انگلیسی

Conformational features of palytoxin and acetylated palytoxin were investigated by detailed analyses of NOESY spectra. The conformational differences between palytoxin and acetylated palytoxin may account for the difference in the assembly state of palytoxin, which exists as an associated dimer, and the acetylated derivative, which exists as a monomer in aqueous solution. Two palytoxin units in the dimer may come in contact with each other at the hydrophobic region (C21-40) and the region around two conjugated double bonds (C60-84). The amino group of palytoxin is important for biological activities via Na/K ATPase, but it was not found to be involved in the contact faces of the two palytoxin units. This information should aid in revealing how palytoxin interacts with Na/K ATPase.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Tetrahedron - Volume 64, Issue 33, 11 August 2008, Pages 7718-7723
نویسندگان
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