کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5225517 1383549 2006 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Nucleophilic aromatic substitutions on 4,5-dicyanopyridazine. Pyrrole and indole systems as carbon nucleophiles
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Nucleophilic aromatic substitutions on 4,5-dicyanopyridazine. Pyrrole and indole systems as carbon nucleophiles
چکیده انگلیسی

4,5-Dicyanopyridazine was found to react with pyrrole and indole counterparts not only as heterocyclic azadiene in inverse electron-demand Hetero Diels-Alder reactions, as previously evidenced, but even as a very reactive heterocyclic electrophile at C-4 carbon, in formal SNAr2 processes where a CN group acts as leaving group. In particular, operating in acetic acid as solvent, nucleophilic addition-elimination sequences allowed a facile access to pyrrolyl- and indolylpyridazines, through the corresponding 1,4-dihydropyridazine adducts.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Tetrahedron - Volume 62, Issue 52, 25 December 2006, Pages 12281-12287
نویسندگان
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