کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5225703 | 1383555 | 2009 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Synthesis of pyrrole urea and pyrrole carbonylurea derivatives
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موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Synthesis of pyrrole urea and pyrrole carbonylurea derivatives Synthesis of pyrrole urea and pyrrole carbonylurea derivatives](/preview/png/5225703.png)
چکیده انگلیسی
A series of urea and carbonylurea distamycin analogs whereby the linker has two NH groups for hydrogen bonding with base pairs of DNA were synthesized. The urea and carbonylurea derivatives are prepared from the in situ generation of pyrrole isocyanate (prepared from compound 3) and acyl isocyanate (compound 9), followed by the reaction with an amine. The synthetic feasibility for the further transformations of the pyrrole urea and pyrrole carbonylurea derivatives was also addressed. The binding abilities of these molecules to calf thymus DNA were evaluated by DNA melting temperature (Tm) analysis.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Tetrahedron - Volume 65, Issue 40, 3 October 2009, Pages 8389-8392
Journal: Tetrahedron - Volume 65, Issue 40, 3 October 2009, Pages 8389-8392
نویسندگان
Meng-Chi Liu, Chi Wi Ong,