کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5226035 1383565 2009 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Synthesis and in vitro activity of 6-amino-2,9-diarylpurines for Mycobacterium tuberculosis
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Synthesis and in vitro activity of 6-amino-2,9-diarylpurines for Mycobacterium tuberculosis
چکیده انگلیسی

A mild method was developed to synthesize 6-amino-2-phenolic-9-alkyl and 9-arylpurines. The new compounds were screened for antibacterial activity against Mycobacterium tuberculosis strain H37Rv. The 9-tolyl derivatives with a dimethylamino or a piperidine substituent in C6 and the 3-hydroxyphenyl or 4-hydroxyphenyl substituent in C2 were highly active against the bacilli.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Tetrahedron - Volume 65, Issue 34, 22 August 2009, Pages 6903-6911
نویسندگان
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