کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5226166 | 1383568 | 2008 | 10 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Preparation of acyclo nucleoside phosphonate analogues based on cross-metathesis
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موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
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چکیده انگلیسی
In our on-going program targeting anti-pox activity, we report here the synthesis of hitherto unknown acyclic nucleoside phosphonates using olefin cross-metathesis (CM) as a key assembly step. Modification at the C-5 position of the uracil moiety was performed under optimized Pd(0)-catalyzed Stille cross-coupling conditions. None of the obtained compounds were active against poxviruses, nor do they exhibit any toxicity.
In our on-going program targeting anti-pox activity, the synthesis of various acyclic nucleoside phosphonates is described using olefin cross-metathesis reaction and Pd(0)-mediated alkylation at the C5-position of the uracil moiety.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Tetrahedron - Volume 64, Issue 16, 14 April 2008, Pages 3517-3526
Journal: Tetrahedron - Volume 64, Issue 16, 14 April 2008, Pages 3517-3526
نویسندگان
Hiroki Kumamoto, Dimitri Topalis, Julie Broggi, Ugo Pradère, Vincent Roy, Sabine Berteina-Raboin, Steven P. Nolan, Dominique Deville-Bonne, Graciela Andrei, Robert Snoeck, Daniel Garin, Jean-Marc Crance, Luigi A. Agrofoglio,