کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5226166 1383568 2008 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Preparation of acyclo nucleoside phosphonate analogues based on cross-metathesis
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Preparation of acyclo nucleoside phosphonate analogues based on cross-metathesis
چکیده انگلیسی

In our on-going program targeting anti-pox activity, we report here the synthesis of hitherto unknown acyclic nucleoside phosphonates using olefin cross-metathesis (CM) as a key assembly step. Modification at the C-5 position of the uracil moiety was performed under optimized Pd(0)-catalyzed Stille cross-coupling conditions. None of the obtained compounds were active against poxviruses, nor do they exhibit any toxicity.

In our on-going program targeting anti-pox activity, the synthesis of various acyclic nucleoside phosphonates is described using olefin cross-metathesis reaction and Pd(0)-mediated alkylation at the C5-position of the uracil moiety.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Tetrahedron - Volume 64, Issue 16, 14 April 2008, Pages 3517-3526
نویسندگان
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