Amberlyst-15: an efficient and reusable catalyst for the Friedel-Crafts reactions of activated arenes and heteroarenes with α-amido sulfones

The heterogeneous Amberlyst-15 catalyst displays efficient catalytic properties for the Friedel-Crafts reactions between an activated arenes or heteroarenes and α-amido sulfones. Various α-amido sulfones on treatment with 1,2,4-trimethoxy benzene give the Friedel-Crafts reaction products in very good yield. The reactions with heteroarenes show moderate yield of the product. The catalyst can be easily recycled without significant loss of activity.

α-Amido sulfones derived from various aldehydes undergo the Friedel-Crafts reactions with electron-rich arenes or heteroarenes in the presence of Amberlyst-15 as the catalyst. Amberlyst-15 can be recycled without significant loss of activity.