Isolation and characterization of two new drimanes from Zygogynum baillonii and synthesis of analogues

Two new drimanes were isolated and characterized from the bark of Zygogynum baillonii, an endemic New-Caledonian tree of the Winteraceae family. One of it shows a significant cytotoxic activity. In order to define structure-activity relationships, analogues were synthesized and their cytotoxicity was evaluated.