Novel megastigmanes with lipid accumulation inhibitory and lipid metabolism-promoting activities in HepG2 cells from Sedum sarmentosum

Novel megastigmanes, neosedumosides I-IV were isolated from Sedum sarmentosum and neosedumosides I-III were found to show lipid accumulation inhibitory activity in HepG2 cells. Furthermore, neosedumosides II and III were found to also show lipid metabolism promoting activity.