Concise diastereospecific pyrrolo[1,2-a][1,4]benzodiazepinone synthesis

A concise synthesis of the novel pyrrolo[1,2-a]benzodiazepine system, by using the metallo carbenoid/spiro-[6,5]-ammonium ylide/Stevens[1,2]-shift with ring-expansion approach, was reported. The overall cascade process resulted stereospecific.

Figure optionsDownload as PowerPoint slide