Novel approach for synthesis of 2:1 permethylated β-cyclodextrin-C60 conjugate

Amphiphilic cyclodextrin-fullerene conjugates have potential biological activity, due to their water solubility. In order to study the influence of the linker of these conjugates on solubility and aggregation, a permethylated β-cyclodextrin-C60 conjugate with a short linker -(CH2)2NHCO-, which is attached to the secondary face of β-cyclodextrin was synthesized. Its solubility in water and its UV spectrum in CH2Cl2 and water were investigated.