کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5227300 1383602 2008 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Mechanistic studies in the synthesis of a series of thieno-expanded xanthosine and guanosine nucleosides
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Mechanistic studies in the synthesis of a series of thieno-expanded xanthosine and guanosine nucleosides
چکیده انگلیسی

During the synthetic pursuit of guanosine (tri-G) and xanthosine (tri-X) tricyclic nucleosides analogues, an interesting side product was discovered. In an effort to uncover the mechanistic factors leading to this result, a series of reaction conditions were investigated. It was found that by varying the conditions, the appearance of the side product could be controlled. In addition, the yield of the desired products could be manipulated to afford either a 50:50 mix of both tri-G and tri-X, or a majority of one or the other. To demonstrate the broad utility of the method, it was also adapted to the synthesis of guanosine and xanthosine from 5-amino-1-β-d-ribofuranosyl-4-imidazolecarboxyamide (AICAR). The mechanistic details surrounding the synthetic efforts are reported herein.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Tetrahedron - Volume 64, Issue 48, 24 November 2008, Pages 10791-10797
نویسندگان
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