Synthesis of sibiricinone A, sibiricinone B and leoheterin

Two labdenolides, sibiricinone A and sibericinone B, and a furo-labdane leoheterin have been synthesized from sclareol, for the first time, establishing in this manner the absolute configuration for these compounds.

Three natural compounds sibiricinone A, sibircinone B and leoheterin have been synthesized from sclareol.