Efficient functionalizations of a pyranosido-pyrimidine scaffold

Efficient reaction conditions have been developed to prepare highly functionalized chiral pyranosido-pyrimidine by regioselective alkylation of the pyranoside ring and palladium-catalyzed cross-coupling reaction on the pyrimidine ring under microwave activation. Such scaffold contains three different functions suitable for selective derivatization and could find applications in the design of peptidomimetics.