کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5227444 | 1383605 | 2009 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Modified palladium-catalyzed regioselective ortho-arylation of sp2 C-H bond substrates with a low catalyst loading
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
A novel and generally applicable system for ortho-arylation of a broad range of sp2 C-H bond substrates such as arylated benzoxazoles, acylated anilines, and pyridines has been developed. The arylation was performed in trifluoroacetic acid (TFA) under air by using PdCl2 as the catalyst with a low catalyst loading of 1Â mol %. And it was found for the first time that the addition of weak base K3PO4 to the acidic solvent could remarkably enhance the reaction rate. The arylated products were isolated in moderate to good yields with high regioselectivity for the substrates containing a meta-substituent. This arylation is tolerant with various functional groups such as CH3, CH3O, CH3CO, Br, and Cl.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Tetrahedron - Volume 65, Issue 4, 24 January 2009, Pages 914-919
Journal: Tetrahedron - Volume 65, Issue 4, 24 January 2009, Pages 914-919
نویسندگان
Fan Yang, Yangjie Wu, Yanan Li, Biao Wang, Junli Zhang,