Efficient synthesis of antifungal pyrimidines via palladium catalyzed Suzuki/Sonogashira cross-coupling reaction from Biginelli 3,4-dihydropyrimidin-2(1H)-ones

Various functionalized pyrimidine have been synthesized from Biginelli 3,4-dihydropyrimodin-2(1H)-ones by the sequence of oxidation, chlorination, and palladium catalyzed Suzuki/Sonogashira reaction and screened for their antibacterial and antifungal activities.