کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5227923 1383619 2006 14 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Synthesis and anti-tubulin evaluation of chromone-based analogues of combretastatins
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Synthesis and anti-tubulin evaluation of chromone-based analogues of combretastatins
چکیده انگلیسی

Twenty new hybrid compounds with both combretastatin and flavone moieties were synthesized. These derivatives are classified according to the position of the trimethoxyphenyl ring at C-2 or C-3 of the chromone and presence or absence of a carbonyl as a linker between C-3 and the aryl ring. Most of these compounds were prepared from hesperidin or naringin, two natural and abundant Citrus flavonoids. Seven of these combretastatin analogues revealed anti-tubulin activity but in a medium range.

Graphical Abstract

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Tetrahedron - Volume 62, Issue 17, 24 April 2006, Pages 4038-4051
نویسندگان
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