PEG-supported pyridylthioesters for racemization-free amide synthesis: a reagent that allows simultaneous product formation and removal from the polymer

Pyridylthioesters anchored to a modified poly(ethylene glycol) of Mw 5000 have been prepared in high yields and employed as a convenient starting material in a new methodology that allowed to perform at the same time the reaction of the supported reagent and the traceless removal of the final product from the polymer support.